That's certainly part of it, yes. But I think much more importantly, dreaming big is a muscle. You have to exercise it from time to time. Each time I come up with a grand vision and sink dozens to hundreds of hours into it, only to walk away unfinished, I learn a bit more about how to make a dream become real.
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In 1874, Fanny Angelina married physician and bacteriologist Walther Hesse, an investigator of air quality and, specifically, air-borne microbes. In the Winter of 1880-81, Hesse became a research student with Koch in Berlin and experienced firsthand the difficulty of growing microbes on gelatine and the other growth media used at the time.